Malignant mesothelioma is known as locally aggressive tumor that rarely metastasizes to distant sites. We report here a very rare case of orbital metastasis from malignant mesothelioma in addition to multiple systemic metastases. The patient with an epithelial subtype of malignant pleural mesothelioma presented himself 16 months after chemoimmunotherapy with decreased visual acuity and increased chest pain. The patient had local progression, and also liver, adrenal, bone and orbital metastases. Palliative systemic chemotherapy was administered for four cycles. He died 22 months after diagnosis of pleural malignant mesothelioma due to progressive disease. [Turk J Cancer 2005;35(1):35- 37].