Intramuscular myxoma is a very rare benign soft tissue tumor. Local recurrence has not been reported after resection. We treated a patient with intramuscular myxoma by radiotherapy due to three recurrences after operation to reduce the tumor volume, to achieve local control and organ preservation. But we cannot obtain sufficient treatment response in our patient. Surgical excision seems to be the most effective treatment. After surgical excision, if recurrence occurs, histopathologic diagnosis should be reviewed. [Turk J Cancer 2006;36(2):75-78].