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Turkish Journal of Cancer
2008, Volume 38, Number 1, Page(s) 020-025
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Results of transthoracic esophagectomy following chemoradiation in locally advanced esophageal cancer
HASAN FEVZİ BATIREL1, CENGİZ GEMİCİ2, BEDRETTİN YILDIZELİ1, TUNÇ LAÇİN1, ASLI GÜL AKGÜL1, SERDAR EVMAN1, HALE BAŞAK ÇAĞLAR4, MAHMUT İLHAN3, MUSTAFA YÜKSEL1
1Marmara University Faculty of Medicine, Department of Thoracic Surgery, İstanbul
2Kartal Lütfü Kırdar Teaching and Research Hospital, Department of Radiation Oncology, İstanbul
3Yüzüncü Yıl University Faculty of Medicine, Department of Medical Oncology, Van
4Marmara University Faculty of Medicine, Department of Radiation Oncology, İstanbul-Turkey

We investigated patients treated with chemoradiation and subsequent esophagectomy. 10 patients were treated between 2004-2007. The chemoradiation regimen was concurrent 4 - 0 Gy radiation with cisplatin and -fluorouracil. Average age was 8 (31-74, 5 females). Clinical stages were T3-4N0-1M0. 9 patients completed the curative or neoadjuvant chemoradiation regimen. Pathologies were squamous cell (n=9) and adenocarcinoma (n=1). All patients underwent esophagectomy via a right thoracic approach, followed by laparotomy and cervical incision. There was no postoperative mortality. 7 patients had complications, 4 of them were major. Postoperative stages were T2N0 (n=3), T3N0 (n=3), T2N1 (n=1) and T3N1 (n=3). One patient died due to local and distant recurrence. Two patients (>70 years) died of non-cancer related causes at 2 and 8 months. Seven patients are alive without disease, 3 of them at 3 , 19 and 18 months. Esophageal resection following concurrent chemoradiation is a high risk procedure that can be applied in well selected patients. [Turk J Cancer 2008;38(1):20-25 ]

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