| Turkish Journal of Cancer |
| 2008, Volume 38, Number 4, Page(s) 184-189 |
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| The regulation of p21Waf1/Cip1, p27Kip1 and p57Kip2 gene expression in response to hydrocortisone, progesterone and ß-estradiol in HL-60 myeloid leukemia cells |
| ESİN MERVE EROL1,2, MİLAS UĞUR1,3, SAMET ÖKSÜZ1,3, TUNÇ FAİK ERSOY1,4, GÜNEŞ ESENDAĞLI5, DİCLE GÜÇ5 |
1Hacettepe University, Institute of Oncology, Department of Basic Oncology, Summer Training Program 2007, Ankara-Turkey
2Hacettepe University, Medical Faculty , 4th term student, Ankara-Turkey
3Middle East Technical University, Faculty of Science, Department of Molecular Biology, 3rd term student, Ankara-Turkey
4St. John’s University, College of Liberal Arts and Sciences, Department of Biological Sciences, 1st term student, NY-USA
5Hacettepe University, Institute of Oncology, Department of Basic Oncology, Ankara-Turkey |
Steroid agents have crucial regulatory effects on cell
differentiation and proliferation of different cell types. In
this study, the influence of progesterone, ß-estradiol and
hydrocortisone on the expression of cyclin dependent
kinase inhibitor (CDKI) genes, p21Waf1/Cip1, p27Kip1 and
p57Kip2 was assessed in HL-60 myeloid leukemia cells.
Although treatment with these steroid agents did not
significantly change the morphology of HL-60 cells,
expression levels of p21 and p27 genes were modulated.
p57 gene was not expressed in HL-60 cells. The overall
data implied that G1/S transition in myeloid leukemia cells
may be primarily regulated through p21Waf1/Cip1 and with a
lesser extent through p27Kip1 expression upon incubation
with steroids. [Turk J Cancer 2008;38(4):184-189]
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